Striking Dichotomy in Outcome of MYCN-Amplified Neuroblastoma in the Contemporary Era

作者：Kushner Brian H^*; Modak Shakeel; Kramer Kim; LaQuaglia Michael P; Yataghene Karima; Basu Ellen M; Roberts Stephen S; Cheung Nai Kong V

来源：Cancer, 2014, 120(13): 2050-2059.

DOI：10.1002/cncr.28687

• neuroblastoma
• contemporary therapy
• MYCN
• induction

BACKGROUND: The authors exploited a large database to investigate the outcomes of patients with high-risk neuroblastoma in the contemporary era. METHODS: All patients with high-risk neuroblastoma aged <12 years who were treated during induction at the authors' institution from 2000 through 2011 were studied, including 118 patients with MYCN-amplified [MYCN(1)] disease and 127 patients aged >18 months with MYCN-nonamplified [MYCN(2)] stage 4 disease. RESULTS: A complete response/very good partial response (CR/VGPR) to induction was correlated with significantly superior event-free survival (EFS) (P < .001) and overall survival (OS) (P < .001) compared with a partial response or less. Patients with MYCN(+) and MYCN(-) disease had similar rates of CR/VGPR to induction (P = .366), and those with MYCN(+) and MYCN(-) disease who attained a CR/VGPR had similar EFS (P=.346) and OS (P=.542). In contrast, only MYCN(1) patients had progressive disease as a response to induction (P < .001), and early death from progressive disease (<366 days after diagnosis) was significantly more common (P < .001) among those with MYCN(+) disease. Overall, among patients who had a partial response or less, MYCN(+) patients had significantly inferior EFS (P < .001) and OS (P < .001) compared with MYCN(-) patients, which accounted for the significantly worse EFS (P=.008) and OS (P=.002) for the entire MYCN(+) cohort versus the MYCN(-) cohort. CONCLUSIONS: Patients with MYCN(-), high-risk neuroblastoma display a broad, continuous spectrum with regard to response and outcome, whereas MYCN(+) patients either have an excellent response to induction associated with good long-term outcome or develop early progressive disease with a poor outcome. This extreme dichotomy in the clinical course of MYCN(+) patients points to underlying biologic differences with MYCN(+) neuroblastoma, the elucidation of which may have far-reaching implications, including improved risk classification at diagnosis and the identification of targets for treatment.

• 出版日期2014-7-1