A family history study of intermittent explosive disorder

作者：Coccaro Emil F^*

来源：Journal of Psychiatric Research, 2010, 44(15): 1101-1105.

DOI：10.1016/j.jpsychires.2010.04.006

• Intermittent Explosive Disorder
• Aggression
• Impulsivity
• Familial Studies

Background Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression Since aggression and impulsivity are under genetic influence IED may be familial
Methods Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria
Results Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives

• 出版日期2010-11