Different Strategies To Improve Lactic Acid Productivity Based on Microorganism Physiology and Optimum Operating Conditions

作者：de Oliveira Regiane Alves^*; Rossell Carlos E Vaz; Lunelli Betania H; Schichi Pedro O M; Venus Joachim; Maciel Filho Rubens

来源：Industrial & Engineering Chemistry Research, 2018, 57(31): 10118-10125.

DOI：10.1021/acs.iecr.8b01655

Despite the broad variety of substrates tested for lactic acid production, most of them have problems, even those with promising results. The use of sugar cane molasses appears as a viable alternative, allowing the development of high-performance lactic acid production with yeast extract. In this study, different strategies are proposed and evaluated to achieve high yield, productivity, and lactic acid concentrations considering the suitable association among strain physiology, osmotic stress, substrates, pH control, and fermentation operational parameters. With these strategies and using molasses as a substrate, it was possible to obtain a yield of 95%, with a productivity of 5.38 g L-1 h(-1), and a titer of 157.95 g/L of lactic acid.

• 出版日期2018-8-8