A low-cost automated flow analyzer based on low temperature co-fired ceramic and LED photometer for ascorbic acid determination

作者：Pessoa Neto Osmundo D^*; dos Santos Vagner B; Vicentini Fernando C; Suarez Willian T; Alonso Chamarro Julian; Fatibello Filho Orlando; Faria Ronaldo C

来源：CENTRAL EUROPEAN JOURNAL OF CHEMISTRY, 2014, 12(3): 341-347.

DOI：10.2478/s11532-013-0377-2

• Ascorbic acid determination
• Flow analysis
• LTCC
• LED photometer
• Multicommutation

An automated flow analyzer based on low temperature co-fired ceramic (LTCC), a solid-phase reactor (SPR) and a low-cost photometer was designed for ascorbic acid (AA) determination in pharmaceutical formulations. It consists of a peristaltic pump, three-way solenoid valves, SPR to chemically convert Cu(II) into Cu(I), and a LTCC device for mixing the liberated copper with bathocuproine and detection. The flow cell in the LTCC employed an ultrabright LED - photodiode photometer. The analyzer successfully determined AA in pharmaceutical formulations. The analytical curve from 8.5x10(-6) to 7.0x10(-4) M gave a detection limit of 7.0x10(-7) M and a RSD of 2.1% for a 2.0x10(-4) M AA solution (n = 10). A high sampling frequency of 102 h(-1) and low reagent and sample consumption (150 A mu L) resulted.

• 出版日期2014-3