Associations Between Urine Excretion of Isoflavonoids and Cognition in Postmenopausal Women in the Women's Isoflavone Soy Health Clinical Trial

作者：St John Jan A; Henderson Victor W; Hodis Howard N; Kono Naoko; McCleary Carol A; Franke Adrian A; Mack Wendy J^*

来源：Journal of the American Geriatrics Society, 2014, 62(4): 629-635.

DOI：10.1111/jgs.12752

• isoflavones
• soy
• menopause
• women's health
• cognition

Objectives
To determine effect of change in urine excretion of isoflavonoids on cognitive change.
Design
Post hoc analysis of isoflavonoid exposure (mean 2.7years) during the randomized, placebo-controlled, double-blind Women's Isoflavone Soy Health trial.
Setting
General community.
Participants
Healthy postmenopausal women (N= 350).
Intervention
Twenty-five grams of isoflavone-rich soy protein (91mg of aglycone weight isoflavones: 52mg genistein, 36mg daidzein, 3mg glycitein) or milk protein-matched placebo provided daily.
Measurements
Overnight urine excretion, fasting plasma levels of isoflavonoids, and cognitive function measured at baseline and endpoint.
Results
Three hundred women (age: mean 61, range 45-92) completed both cognitive assessments and did not use hormone replacement therapy during the trial. Mean on-trial change from baseline in urine excretion of isoflavonoids was not significantly associated with change in a composite score of global cognition (P=.39). Secondary analyses indicated that change in urine excretion of isoflavonoids was inversely associated with change in a factor score representing general intelligence (P=.02) but not with factor scores representing verbal or visual episodic memory. Mean differences in this general intelligence factor score between women in the lowest and highest quartiles of isoflavonoid change were equivalent to an approximate 4.4-year age-associated decline. Analyses based on plasma isoflavonoid levels yielded similar but attenuated results.
Conclusion
In healthy postmenopausal women, long-term changes in isoflavonoids are not associated with global cognition, supporting clinical trial results, although greater isoflavonoid exposure from dietary supplements is associated with decrements in general intelligence but not memory; this finding requires confirmation in future studies.

• 出版日期2014-4