Activity of caspofungin and voriconazole against clinical isolates of Candida and other medically important Yeasts by the CLSI M-44A disk diffusion method with neo-sensitabs tablets

作者：Carrillo Munoz A J^*; Quindos G; del Valle O; Santos P; Giusiano G; Ezkurra P A; Estivill M D; Casals J B

来源：Chemotherapy, 2008, 54(1): 38-42.

DOI：10.1159/000112414

• disk diffusion
• susceptibility
• Candida
• Neo-sensitabs
• caspofungin
• voriconazole
• fluconazole
• amphotericin B
• ketoconazole
• Itraconazole

In vitro activity of caspofungin and vori conazole against 184 clinical isolates of Candida and other medically important yeasts in comparison with that of fluconazole, ketoconazole, itraconazole and amphotericin B was determined by using a disk diffusion method (Neo-Sensitabs) standardized according to the recommendations of the CLSI documents M44-A and M44-S1 (same medium: Mueller-Hinton plus methylene blue; inoculum and minimal inhibitory concentration/zone breakpoints). Seventy-two percent of clinical isolates were susceptible to caspofungin, 23.6% showed an intermediate susceptibility (most of them were Candida parapsilosis) and 4.3% were resistant (values for Candida spp. were 71.2, 23.8 and 5%, respectively). For voriconazole, 96.7% of clinical isolates were susceptible and 3.3% were resistant (Candida spp.: 96 and 3.8%, respectively). Both caspofungin and voriconazole showed high activity against a wide variety of clinically important yeasts.

• 出版日期2008
• 单位河北医科大学