Association of serum omentin-1 concentrations with the presence and severity of preeclampsia

作者：Liu, Haiping; Wu, Jianfeng; Wang, Haiyu; Sheng, Lianbing; Tang, Ning; Li, Yunfei; Hao, Tianyu^*

来源：Annals of Clinical Biochemistry, 2015, 52(2): 245-250.

DOI：10.1177/0004563214541247

• Omentin-1
• inflammation
• preeclampsia

Background Inflammation is involved in the pathogenesis of preeclampsia. Omentin is a newly discovered adipokine that possesses an anti-inflammatory function. The aim of this study was to determine the association of serum omentin-1 concentration with the presence and severity of preeclampsia.
Methods Serum concentrations of omentin-1 were measured in 128 women with preeclampsia and 96 women with uncomplicated pregnancies using an enzyme-linked immunosorbent assay method.
Results Patients with preeclampsia had significantly lower serum concentrations of omentin-1 compared to healthy controls. In addition, those patients with severe preeclampsia had significantly lower concentrations of serum omentin-1 compared to those with mild preeclampsia. Simple linear regression analysis showed that in patients with preeclampsia the serum concentrations of omentin-1 showed significant correlation with body mass index (P<0.001), systolic blood pressure (P<0.05) and homeostasis model assessment of insulin resistance (P<0.001).
Conclusion Decreased concentrations of serum omentin-1 appear to be associated with the presence and severity of preeclampsia.

• 出版日期2015-3
• 单位中国人民解放军济南军区总医院; 山东中医药大学