Urease inhibitory potential of Zizyphus oxyphylla Edgew. extracts and isolated compounds

作者：Kaleem Waqar Ahmad; Nisar Muhammad; Qayum Mughal; Zia Ul Haq Muhammad; Choudhary Muhammad Iqbal; Ercisli Sezai^*

来源：Turkish Journal of Medical Sciences, 2013, 43(4): 497-500.

DOI：10.3906/sag-1208-28

• Zizyphus oxyphylla
• cyclopeptide alkaloids
• urease

Aim: To determine the urease inhibitory potential of extracts and isolated compounds from Zizyphus oxyphylla Edgew.
Materials and methods: Methanolic extracts and subsequent fractions of Z. oxyphylla stem and 3 isolated compounds from the roots of Z. oxyphylla were obtained through column chromatography and subjected to in vitro urease inhibition.
Results: Three fractions (n-hexane, ethyl acetate, and butanol fractions) showed good to excellent activity, while the chloroform fraction showed nonsignificant activity. Amongst the isolated compounds, oxyphylline D (1) was the most active of the 3 isolated cyclopeptide alkaloids, followed by nummularin R (3) and nummularin C (2).
Conclusion: Z. oxyphylla has the potential to be used in the treatment of various complications produced by urease enzymes, such as gastric ulcers.

• 出版日期2013