Understanding, preventing and eradicating Klebsiella pneumoniae biofilms

作者：Ribeiro Suzana Meira; Cardoso Marlon Henrique; Candido Elizabete de Souza; Franco Octavio Luiz

来源：Future Microbiology, 2016, 11(4): 527-538.

DOI：10.2217/fmb.16.7

• antibiofilm agents
• bacterial resistance
• biofilm
• infections
• Klebsiella pneumonia

The ability of pathogenic bacteria to aggregate and form biofilm represents a great problem for public health, since they present extracellular components that encase these microorganisms, making them more resistant to antibiotics and host immune attack. This may become worse when antibiotic-resistant bacterial strains form biofilms. However, antibiofilm screens with different compounds may reveal potential therapies to prevent/treat biofilm infections. Here, we focused on Klebsiella pneumoniae, an opportunistic bacterium that causes different types of infections, including in the bloodstream, meninges, lungs, urinary system and at surgical sites. We also highlight aspects involved in the formation and maintenance of K. pneumoniae biofilms, as well as resistance and the emergence of new trends to combat this health challenge.

• 出版日期2016