A novel formulation of L-thyroxine (L-T4) reduces the problem of L-T4 malabsorption by coffee observed with traditional tablet formulations

作者：Vita Roberto^*; Saraceno Giovanna; Trimarchi Francesco; Benvenga Salvatore

来源：Endocrine, 2013, 43(1): 154-160.

DOI：10.1007/s12020-012-9772-2

• L-Thyroxine therapy
• L-T4 formulations
• L-Thyroxine malabsorption
• Coffee
• Hypothyroidism

The purpose of this work is to evaluate if the coffee-associated malabsorption of tablet levothyroxine (l-T4) is reduced by soft gel capsule. We recruited 8 patients with coffee-associated l-T4 malabsorption including one hypothyroid patient. For 6 months, the patients were switched to the capsule maintaining the l-T4 daily dose. Patients took the capsule with water, having coffee 1 h later (proper habit, PH) on days 1-90, or with coffee a parts per thousand currency sign5 min later (improper habit, IH) on days 91-180. After 6 months, 2 patients volunteered for an acute loading test of 600 mu g l-T4 (capsule) ingested with water (PH) or with coffee (IH). In the single hypothyroid patient, the post-switch TSH ranged 0.06-0.16 mU/L (PH) versus 5.8-22.4 mU/L pre-switch (PH) and 0.025-0.29 mU/L (IH) versus 26-34 mU/L pre-switch (IH). In the other 7 patients, post-switch TSH was 0.41 +/- A 0.46 (PH) versus 0.28 +/- A 0.20 pre-switch (PH) (P = 0.61) and 0.34 +/- A 0.30 (IH) versus 1.23 +/- A 1.47 pre-switch (IH) (P %26lt; 0.001). Importantly, TSH levels in PH versus IH habit did not differ post-switch (P = 0.90), but they did pre-switch (P %26lt; 0.0001). The proportions of post-switch TSH levels %26lt; 0.10 mU/L with PH (33.3 %) or with IH (33.3 %) were borderline significantly greater than the corresponding pre-switch levels with PH (10.3 %) (P = 0.088) or with IH (0 %) (P = 0.0096). In the two volunteers, the l-T4 loading test showed that coffee influenced l-T4 pharmacokinetics minimally. Soft gel capsules can be used in patients who are unable/unwilling to change their IH of taking l-T4.

• 出版日期2013-2