A Mesoscale Abscisic Acid Hormone Interactome Reveals a Dynamic Signaling Landscape in Arabidopsis

作者：Lumba Shelley; Toh Shigeo; Handfield Louis Francois; Swan Michael; Liu Raymond; Youn Ji Young; Cutler Sean R; Subramaniam Rajagopal; Provart Nicholas; Moses Alan; Desveaux Darrell^*; McCourt Peter

来源：Developmental Cell, 2014, 29(3): 360-372.

DOI：10.1016/j.devcel.2014.04.004

The sesquiterpenoid abscisic acid (ABA) mediates an assortment of responses across a variety of kingdoms including both higher plants and animals. In plants, where most is known, a linear core ABA signaling pathway has been identified. However, the complexity of ABA-dependent gene expression suggests that ABA functions through an intricate network. Here, using systems biology approaches that focused on genes transcriptionally regulated by ABA, we defined an ABA signaling network of over 500 interactions among 138 proteins. This map greatly expanded ABA core signaling but was still manageable for systematic analysis. For example, functional analysis was used to identify an ABA module centered on two sucrose nonfermenting (SNF)-like kinases. We also used coexpression analysis of interacting partners within the network to uncover dynamic subnetwork structures in response to different abiotic stresses. This comprehensive ABA resource allows for application of approaches to understanding ABA functions in higher plants.

• 出版日期2014-5-12