A novel one pot room temperature ionic liquid mediated synthesis of 1,5-benzodiazepine ribofuranosides

作者：Yadav Ashok K^*; Kumar Manoj; Yadav Tripti; Jain Renuka

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2010, 49(4): 461-468.

• Benzodiazepines
• ribofuranosides
• ionic liquid
• o-phenylenediamine
• ketones

A novel one pot ecofriendly synthesis or 7-substituted/7,8-disubstituted-2,2,4-trisubstituted-1-(2',3',5'-tri-O-benzoyl-beta-D-ribofuranosyl)-2,3-dihydro-1,5-benzodiazepines have been accomplished stepwise, i e reacting o-phenylenediamine and a ketone in the first step followed by addition of beta-D-ribofuranose-1-bromo-2,3,5-tribenzoate. The ionic liquids employed are 1,3-di-n-butylmidazolium bromide [BBIM]Br, 1-butyl-3-methylimidazolium bromide [BMIM]Br. 1-butyl-3-methylimidazolium tetrafluoroborate, [BMIM]BF(4). 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM]PF(6), and 1-methoxyethyl-3-methylimidazolium mesylate [MOEMIM]Ms. The yields (72-90%) of the targeted compounds are excellent

• 出版日期2010-4