科研之友
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摘要
Background/Aims: Many women with polycystic ovary syndrome (PCOS) exhibit insulin resistance. Adipose tissue plays an important role in insulin resistance, and adipokines including tumor necrosis factor (TNT)-alpha and adiponectin are altered in PCOS. Insulin-like growth factor binding protein-3 (IGFBP-3), alone or in conjunction with other adipokines, is also associated with insulin resistance. We evaluated the effects of TNP-alpha, adiponectin, and IGPBP-3 on insulin sensitivity and the relationships among these proteins in women with PCOS. %26lt;br%26gt;Methods: We recruited 40 women with PCOS and 40 age- and body mass index (BMI)-matched regular cycling women (controls). The women were divided into obese (BMI %26gt;= 25 kg/m(2)) and nonobese (BMI %26lt; 25 kg/m(2)) groups. Anthropornetric measurements were performed, and serum levels of TNF-alpha, adiponectin, and IGPBP-3 were determined. Insulin sensitivity was estimated using the metabolic clearance rate (MCR) of glucose calculated from the oral glucose tolerance test. %26lt;br%26gt;Results: Serum levels of TNF-alpha and IGFBP-3 did not differ between the PCOS and control groups, but adiponectin levels in the PCOS group were lower than those in control women in the nonobese group (p %26lt; 0.05). TNP-alpha, adiponectin, and IGFBP-3 levels were not correlated with each other in women with PCOS, but a significant positive correlation was observed between adipon.ectin levels and MCR (p %26lt; 0.05). Multiple regression analysis revealed that adiponectin levels were significantly associated with insulin sensitivity (p %26lt; 0.05) in women with PCOS. %26lt;br%26gt;Conclusions: IGPBP-3 and TNP-alpha levels were not associated with insulin sensitivity, but adiponectin levels were related to insulin sensitivity in women with PCOS.
- 出版日期2013-7
