Seawater and freshwater challenges affect the insulin-like growth factors IGF-I and IGF-II in liver and osmoregulatory organs of the tilapia

作者：Link Karl; Berishvili Giorgi; Shved Natallia; D'Cotta Helena; Baroiller Jean Francois; Reinecke Manfred^*; Eppler Elisabeth

来源：Molecular and Cellular Endocrinology, 2010, 327(1-2): 40-46.

DOI：10.1016/j.mce.2010.05.011

• Osmoregulation
• Teleost
• Liver
• Gills
• Kidney
• Intestine
• Growth hormone

Contradictory studies suggest IGF-I in fish liver and gills is involved in osmoregulation, but nothing is known about the kidney and intestine's role nor about IGF-II's role in any organ Tilapia were transferred from freshwater (FW) to seawater (SW) for 1 week (wk) and retransferred to FW for another week. At 4 h, 1 d, 2 d, 3d and 1 wk after SW-transfer and FW-retransfer IGF-I, IGF-II and growth hormone receptor (GHR1) mRNA were measured by real-time PCR. Hepatic IGF-I, IGF-II and GHR1 mRNA were downregulated in parallel after SW-transfer, recovered and were again downregulated after FW-retransfer. In gills, IGF-I, IGF-II and GHR1 were upregulated synchronously after SW-transfer and, partially also after FW-retransfer The renal genes were downregulated after SW-transfer and partially upregulated after FW-retransfer Persisting upregulation in intestinal IGF-I mRNA o

• 出版日期2010-10-7