Mechanisms of mechanotransduction

作者：Orr AW; Helmke BP; Blackman BR; Schwartz MA^*

来源：Developmental Cell, 2006, 10(1): 11-20.

DOI：10.1016/j.devcel.2005.12.006

Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechano-transducers.

• 出版日期2006-1