Traditional Resuscitative Practices Fail to Resolve Metabolic Acidosis in Morbidly Obese Patients After Severe Blunt Trauma

作者：Winfield Robert D; Delano Matthew J; Lottenberg Lawrence; Cendan Juan C; Moldawer Lyle L; Maier Ronald V; Cuschieri Joseph^*

来源：Journal of Trauma-Injury Infection and Critical Care, 2010, 68(2): 317-328.

DOI：10.1097/TA.0b013e3181caab6c

• Obesity
• Trauma
• Resuscitation
• End points of resuscitation
• Metabolism

Background: Obesity is a risk factor for postinjury complications; in particular, obese patients develop multiple organ failure (MOF) at a greater rate than do normal weight counterparts. Evaluation of differences in resuscitative practices altered by body mass index (BMI) might provide an explanation for the increased risk of MOF seen in these high-risk patients.
Methods: We used prospectively collected multicenter data to retrospectively compare patients grouped by BMI with regard to resuscitation volumes and traditional end points during the first 48 hours after injury. Marshall MOF score was used as the primary outcome measure.
Results: One thousand sixty-six patients were analyzed, with 877 meeting inclusion and exclusion criteria. All patients received similar volumes of resuscitation per kilogram lean and ideal body weight. Morbidly obese patients attained greater central venous pressures but otherwise differed little in attainment of standard cardiovascular end points. Despite this, morbidly obese patients resolved base deficit more slowly and remained in metabolic acidosis for 48 hours postinjury. Morbidly obese patients with persistent metabolic acidosis developed MOF at a significantly greater rate than did normal weight patients with or without persistent metabolic acidosis.
Conclusions: Morbidly obese trauma patients show prolonged metabolic acidosis despite receiving similar volumes and attaining similar end points of resuscitation when compared with patients in other BM I groups. Inadequate resuscitation based on inaccurate end points and metabolic disturbances associated with increased BMI are likely responsible; identification of the etiology, sources. and consequences of this acidosis may provide further insight into the susceptibility of the morbidly obese patient to develop postinjury organ failure.

• 出版日期2010-2