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摘要
A novel and efficient method was developed for the liquid-phase synthesis of N-1,N-4-disubstituted-benzodiazepine-2,5-diones with 2-chloro-5-nitrobenzoic acid as initiating material via 4 step reactions containing esterification, "Ulmn reaction", acylation, alkylation and cyclization. The reaction conditions were mild and the overall yields of the products ranged from 45% to 71%.
- 出版日期2009-5-25
- 单位湖北大学
