A new enantioselective approach to the core structure of hypoxia selective prodrugs related to the duocarmycins

Heinrich Daniel M<sup>*</sup>; Youte Jean Jacques; Denny William A; Tercel Moana

doi:10.1016/j.tetlet.2011.10.105

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A new enantioselective approach to the core structure of hypoxia selective prodrugs related to the duocarmycins

作者：Heinrich Daniel M^*; Youte Jean Jacques; Denny William A; Tercel Moana

来源：Tetrahedron Letters, 2011, 52(51): 7000-7003.

DOI：10.1016/j.tetlet.2011.10.105

摘要

The indoline scaffold of hypoxia selective prodrugs of DNA-alkylating agents related to the duocarmycin natural products was synthesized via an enantioselective Friedel-Crafts alkylation. Easily accessible starting materials and good stereoselectivity in the alkylation step provide an enantioselective synthesis of the DNA-alkylating subunit.