Azalomycin F4a 2-ethylpentyl ester, a new macrocyclic lactone, from mangrove actinomycete Streptomyces sp 211726

作者：Yuan, Gan Jun; Hong, Kui^*; Lin, Hai Peng; Li, Jia

来源：Chinese Chemical Letters, 2010, 21(8): 947-950.

DOI：10.1016/j.cclet.2010.03.025

• Streptomyces sp 211726
• Azalomycin F-4a 2-ethylpentyl ester
• Antifungal activity
• Cytotoxity

Azalomycin F-4a 2-ethylpentyl ester, a new 36-membered macrocyclic lactone antibiotic, was isolated from mangrove actinomycete Streptomyces sp. 211726. Its structure was elucidated on the basis of spectroscopic data. The compound showed broad-spectrum antifungal activity and moderate cytotoxicity against human colon tumor cell HCT-116.

• 出版日期2010-8
• 单位国家新药筛选中心; 海南医学院; 中国科学院; 中国热带农业科学院; 中国科学院上海药物研究所