Steroid Receptor Coactivator-1 Mediates Estrogenic Actions to Prevent Body Weight Gain in Female Mice

作者：Zhu Liangru; Yang Yongjie; Xu Pingwen; Zou Fang; Yan Xiaofeng; Liao Lan; Xu Jianming; O' Malley Bert W; Xu Yong^*

来源：Endocrinology, 2013, 154(1): 150-158.

DOI：10.1210/en.2012-2007

Estrogen receptor-alpha (ER alpha) expressed by hypothalamic proopiomelanocortin and steroidogenic factor-1 neurons largely mediates the antiobesity effects of estrogens in females. However, the critical molecular events that are coupled to ER alpha and mediate estrogenic effects on energy balance remain unknown. In the current study, we demonstrated that steroid receptor coactivator-1 (SRC1), a nuclear receptor coactivator, is abundantly expressed by both proopiomelanocortin and steroidogenic factor-1 neurons. We further showed that central administration of an ER alpha agonist, propyl pyrazole triol, acutely increases physical interaction between SRC1 and ER alpha in the hypothalamus. Finally, we demonstrated that the effects of estrogens on energy homeostasis are significantly blunted in female mice lacking SRC1 globally. Collectively our results indicate that SRC1 is functionally required to mediate the antiobesity effects of estrogen-ER alpha signals. (Endocrinology 154: 150-158, 2013)

• 出版日期2013-1
• 单位华中科技大学