No evidence for association between NOTCH4 and schizophrenia in a large family-based and case-control association analysis

作者：Ivo Roland; Schulze Thomas G; Schumacher Johannes; Kesper Kristina; Mueller Daniel J; Kremer Ilana; Dobrusin Michael; Mujaheed Mustafa; Murad Ibrahim; Blanaru Monika; Bannoura Isaam; Reshef Alon; Bachner Melman Rachel; Ebstein Richard P; Propping Peter; Belmaker Robert H; Maier Wolfgang; Rietschel Marcella; Noethen Markus M; Cichon Sven^*

来源：Psychiatric Genetics, 2006, 16(5): 197-203.

DOI：10.1097/01.ypg.0000218619.50386.7c

• age of onset
• association analysis
• NOTCH4
• schizophrenia
• single nucleotide polymorphism

Objectives An analysis of 80 British parent-off spring trios by Wei and Hemmings in 2000 revealed thre1e out of five markers within the NOTCH4 locus to be strongly associated with schizophrenia. In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin.
Methods Our study population comprised a German case-control sample (n = 512 schizophrenia patients and n = 232 controls) and two independent parent-off spring trio samples of German (n = 159 trios) and Palestinian-Arab (n = 208 trios) descent We examined a total of ten single nucleotide polymorphisms within the NOTCH4 locus and the adjacent loci, spanning a region of approximately 100 kb.
Results Neither single marker nor haplotype analyses showed association with schizophrenia. In addition, analyses of the German case-control and trio samples revealed no significant association between NOTCH4 polymorphisms and early-onset schizophrenia.
Conclusions Our results suggest that NOTCH4 is unlikely to play a major role in the genetic predisposition to schizophrenia in the German or the Palestinian-Arab population.

• 出版日期2006-10
• 单位上海市精神卫生中心