Anti-inflammatory effects of 1-isothiocyanato-7-(methylsulfonyl) heptane by suppressing the NF-kappa B signaling pathway

作者：Lim Haesoon; Kim Hye Joung; Jeong Hana; Park Hae Ryoung^*

来源：European Journal of Inflammation, 2017, 15(2): 57-65.

DOI：10.1177/1721727X17719600

• inflammation
• iNOS
• isothiocyanates
• nitric oxide
• NF kappa-B pathway

The anti-inflammatory roles of I7456 (1-isothiocyanato-7-(methylsulfonyl) heptane or 7-methylsulfonylheptyl isothiocyanate), a plant-derived and sulfur-containing isothiocyanate, were investigated. When macrophage cells (RAW 264.7) were challenged with lipopolysaccharide (LPS), nitric oxide (NO) increased. However, NO was remarkably reduced upon I7456 treatment. I7456 strongly reduced the expression of IL-6, IL-10, IL-1 beta, and iNOS. Interestingly, heme oxygenase-1 (HO-1) was strongly induced without LPS challenge. LPS-induced NF kappa-B (nuclear factor kappa-light-chain-enhancer of activated B cells) translocation into the nucleus was inhibited by I7456 in a dose-dependent manner. I7456 markedly reduced the phosphorylation level of IB, and NF kappa-B remained inactivated. I7456 could play important roles in anti-inflammatory responses and have implications for anticancer treatments.

• 出版日期2017-8