Multiple MAGE-A genes as surveillance marker for the detection of circulating tumor cells in patients with ovarian cancer

作者：Sang, Meixiang; Wu, Xiaohua^*; Fan, Xiaojie; Sang, Meijie; Zhou, Xinliang; Zhou, Nan

来源：Biomarkers, 2014, 19(1): 34-42.

DOI：10.3109/1354750X.2013.865275

• Circulating tumor cells
• MAGE
• ovarian cancer
• surveillance marker

Ovarian cancer is a leading cause of death among gynecologic malignancies. In this study, we reported the expression of melanoma-associated antigens A (MAGE-A) genes in peripheral blood from 80 patients with ovarian cancer and 30 healthy donors. MAGE-As expression was associated with the factors indicating poor prognosis. The expressions of MAGE-As and each individual MAGE-A genes were also associated with low overall survival of patients with ovarian cancer. Our results suggested MAGE-A genes may have the potential to be surveillance markers for the detection of circulating tumor cells and represent a poor prognosis for patients with ovarian cancer.

• 出版日期2014-2
• 单位中国人民解放军白求恩国际和平医院; 河北医科大学