Novel alpha-Glucosidase Activator from Pulicaria undulata

作者：Rasool Nasir^*; Rashid Muhammad Abid; Khan Saleha Suleman; Ali Zulfiqar; Zubair Muhammd; Ahmad Viciar Uddin; Khan Shamsun Nahar; Choudhary M Iqbal; Tareen Rasool Bakhsh

来源：Natural Product Communications, 2013, 8(6): 757-759.

• Pulicaria undulata
• Pulicarside
• Paniculoside
• alpha-Glucosidase activator
• alpha-Glucosidase inhibition

A new ent-kaurane type diterpene glucoside, pulicarside (1), together with three known terpenoids, paniculoside IV (2, diterpene), ent-16, 17-dihydroxy-(-)-kauran-19-oic acid (3, diterpene), and 2 alpha-hydroxy alantolactone (4, sesquiterpene) have been isolated from Pulicaria undulata L. Their structures were determined with the help of spectral studies. Pulicarside (1) showed alpha-glucosidase activator activity, whereas its hydrolyzed product ent-16, 17-dihydroxy-(-)-kauran-19-oic acid (3) exhibited strong alpha-glucosidase inhibitory activity. Paniculoside IV (2) also shows high inhibitory potency compared with the standard drug acarbose.

• 出版日期2013-6