Body mass index and the risk of incident functional disability in elderly Japanese The OHSAKI Cohort 2006 Study

作者：Zhang Shu^*; Tomata Yasutake; Sugiyama Kemmyo; Kaiho Yu; Honkura Kenji; Watanabe Takashi; Tanji Fumiya; Sugawara Yumi; Tsuji Ichiro

来源：Medicine, 2016, 95(31): e4452.

DOI：10.1097/MD.0000000000004452

• body mass index
• cause-specific disability
• elderly people
• ideal BMI range
• incident disability

The relationship between the body mass index (BMI) and the incidence of cause-specific disability remains unclear.
We conducted a prospective cohort study of 12,376 Japanese individuals aged >= 65 years who were followed up for 5.7 years. Information on BMI and other lifestyle factors was collected via a questionnaire in 2006. Functional disability data were retrieved from the public Long-term Care Insurance database. BMI was divided into 6 groups (<21, 21-<23, 23-<25, 25-<27[reference], 27-<29 and >= 29). Hazard ratios and 95% confidence intervals for cause-specific disability were estimated using Cox proportional hazards regression models.
A U-shaped relationship between BMI and functional disability was observed, with a nadir at 26. The nadir BMI values with the lowest disability risk were 28 for dementia, 25 for stroke, and 23 for joint disease. A low BMI (<23) was a risk factor for disability due to dementia, the HR values (95% CI) being 2.48 (1.70-3.63) for BMI <21 and 2.25 (1.54-3.27) for BMI 21 to < 23; a high BMI (>= 29) was a risk factor for disability due to joint disease, the HR value (95% CI) being 2.17 (1.40-3.35). There was no significant relationship between BMI and disability due to stroke.
The BMI nadirs for cause-specific disability differed: a low BMI (<23) was a risk factor for disability due to dementia, and a high BMI (>= 29) was a risk factor for disability due to joint disease. Because BMI values of 23 to <29 did not pose a significantly higher risk for each cause of disability, this range should be regarded as the optimal one for the elderly population.

• 出版日期2016-8