Ascorbate- and Zinc-Responsive Parkinsonism

作者：Quiroga Martha J; Carroll David W; Brown Thomas M^*

来源：Annals of Pharmacotherapy, 2014, 48(11): 1515-1520.

DOI：10.1177/1060028014545356

• vitamins
• psychiatry
• Parkinson disease
• nutrition
• central nervous system

Objective: To report a case of Parkinsonisnn rapidly responsive to intravenous replacement of vitamin C and zinc. Case Summary: A 66-year-old man with Parkinsonisnn, pleural effusion, and bipolar disorder was found to have low serum vitamin C and zinc levels. Intravenous replacement of these micronutrients led to resolution of the movement disorder in less than 24 hours. Discussion: Parkinsonism has been associated with vitamin C deficiency, and recent cases of scurvy complicated by Parkinsonisnn have responded well to intravenous replacement of vitamin C. In this case, deficiency of zinc may have contributed to the development of a movement disorder. The likely pathophysiology of, and treatment recommendations for, Parkinsonism linked to deficiencies of vitamin C and zinc are reviewed. Conclusions: Whereas vitamin C has a strong link with Parkinsonism, the potential role of zinc has only been suspected. This case report highlights some of the potential links between zinc deficiency and Parkinsonism.

• 出版日期2014-11