Acetophenone glycosides from the roots of Euphorbia fischeriana and their inhibitory effects against Mycobacterium smegmatis

作者：Huang, Shan-Shan; Li, Ping; Zhang, Bao-Jing; Deng, Sa; Zhang, Hou-Li; Sun, Cheng-Peng; Huo, Xiao-Kui; Tian, Xiang-Ge; Ma, Xiao-Chi; Wang, Chao^*

来源：Phytochemistry Letters, 2017, 19: 151-155.

DOI：10.1016/j.phytol.2016.12.032

• Euphorbia fischeriana
• Acetophenones
• Mycobacterium smegmatis
• Cytotoxic

An extract of the Euphorbia fischerian root, used in the preparation of "Jieheling tablets" in China, exhibited bioactivity toward lymphoid tuberculosis and pulmonary tuberculosis. The present investigation identified three new acetophenone glycosides (1-3), and five known acetophenones (48). Materials were purified via chromatography and identified through spectroscopic analysis. Additionally, the potential anti-tuberculosis effects of the isolated acetophenones were evaluated using a Mycobacterium smegmatis model. Compounds 7 and 8 displayed weak inhibitory effects against Mycobacterium smegmatis, with MIC values of 0.1 and 0.2 mg/ ml, respectively, being observed. All compounds were inactive when tested their cytotoxic activity on six human cancer cell lines.

• 出版日期2017-3
• 单位大连医科大学