Acute Kidney Injury in a Patient with Nephrotic Syndrome due to Focal Segmental Glomerular Nephritis Induced by a Single Oral Administration of High-dose Bisphosphonate (Minodronate)

作者：Komada Takanori; Morishita Yoshiyuki^*; Kitamura Masafumi; Iwazu Kana; Numata Akihiko; Kobayashi Takahisa; Yamamoto Hisashi; Akimoto Tetsu; Saito Osamu; Ando Yasuhiro; Takemoto Fumi; Muto Shigeaki; Yumura Wako; Kusano Eiji

来源：Internal Medicine, 2013, 52(12): 1383-1387.

DOI：10.2169/internalmedicine.52.0094

• minodronate
• acute kidney injury
• nephrotic syndrome
• focal segmental glomerular sclerosis

We herein report the case of a 75-year-old man who developed an increased serum creatinine level (4.93 mg/dL) and oliguria with massive proteinuria (7.14 g/day) on the second day after a single oral administration of high-dose (56 mg) minodronate. The histology of a renal biopsy showed one area of glomerular sclerosis among 20 glomeruli with global foot process effacement of podocytes and mild infiltration of lymphocytes and eosinophils into the interstitial space. Acute kidney injury in nephrotic syndrome due to focal segmental glomerular sclerosis induced by minodronate was diagnosed. Following cessation of minodronate without the administration of immunosuppressive agents, the patient%26apos;s renal function and proteinuria markedly improved.

• 出版日期2013