A Simple Reduction of Imines to Biologically Important Secondary Amines Using Sodium Borohydride/Alumina in Solid-Phase

作者：Tabane Tumelo Hendrick; Singh Girija Shankar^*

来源：Proceedings of the National Academy of Sciences India Section A-Physical Sciences, 2014, 84(4): 517-521.

DOI：10.1007/s40010-014-0130-z

• Imines
• NaBH4-Al2O3
• sec-Amines

The present paper describes a simple reduction of N-arylidene- and N-heteroarylideneamines from salicylaldehyde, thiophene-2-carboxaldehyde and N-methylindole-3-carboxaldehyde to the corresponding secondary amines by a simple method using sodium borohydride on neutral alumina under solvent-free conditions. The new products have been characterized by analytical and spectral data (IR, H-1 and C-13 NMR, MS). The mass spectra of N-substituted benzhydryl amines (alkyl amines) showed the molecular ion peak corresponding to M+ -2 and not M+ as shown by the N-substituted aromatic amines that has been explained by the possibility of formation of a more stable radical in the former type.

• 出版日期2014-12