Deciphering the molecular basis of venous thromboembolism: where are we and where should we go?

作者：Morange Pierre Emmanuel^*; Tregouet David Alexandre

来源：British Journal of Haematology, 2010, 148(4): 495-506.

DOI：10.1111/j.1365-2141.2009.07975.x

• genetics of thrombosis and haemostasis
• epidemiology
• venous thrombosis

Venous thromboembolism (VTE) is a frequent disease that has a major genetic component of risk. However, known identified genetic risk factors account for <30% of idiopathic (without any environmental origin) VTE cases. This article aims to review the lessons learnt during recent decades in the field of the genetics of VTE, describe the present state-of-art methods and discuss promising themes for finding new susceptibility loci.

• 出版日期2010-2