Atmospheric Pressure Drift Tube Ion Mobility-Orbitrap Mass Spectrometry: Initial Performance Characterization

作者：Keelor Joel D; Zambrzycki Stephen; Li Anyin; Clowers Brian H; Fernandez Facundo M^*

来源：Analytical Chemistry, 2017, 89(21): 11301-11309.

DOI：10.1021/acs.analchem.7b01866

Atmospheric pressure drift tube ion mobility spectrometry (AP-DTIMS) was coupled with Fourier transform Orbitrap mass spectrometry. The performance capabilities of this versatile new arrangement were demonstrated for different DTIMS ion gating operation modes and Orbitrap mass spectrometer parameters with regard to sensitivity and resolving power. Showcasing the optimized AP-DTIMS-Orbitrap MS system, isobaric peptide and sugar isomers were successfully resolved and the identities of separated species validated by high-energy collision dissociation experiments.

• 出版日期2017-11-7