Blood Pressure in 12-Year-Old Children Is Associated With Fatty Acid Composition of Human Milk The Prevention and Incidence of Asthma and Mite Allergy Birth Cohort

作者：van Rossem Lenie^*; Wijga Alet H; de Jongste Johan C; Koppelman Gerard H; Oldenwening Marieke; Postma Dirkje S; Abrahamse Berkeveld Marieke; van de Heijning Bert; Brunekreef Bert; Smit Henriette A

来源：Hypertension, 2012, 60(4): 1055-+.

DOI：10.1161/HYPERTENSIONAHA.112.197830

• fatty acids
• EPA
• DHA
• n-3 LC PUFA
• human milk
• blood pressure
• childhood

Breastfed individuals have a lower blood pressure than formula-fed individuals. Supplementation with n-3 long-chain polyunsaturated fatty acids in adults is also associated with a lower blood pressure. We studied whether children receiving human milk with a relatively high content of n-3 long-chain polyunsaturated fatty acids have a lower blood pressure at age 12 years, and, if so, whether this association is explained by the n-3 long-chain polyunsaturated fatty acids content in erythrocyte membranes at age 12 years. Within a 12-year follow-up of a population-based birth cohort, we compared blood pressure of 205 never-breastfed children and 109 children who had fatty acid composition of their mothers%26apos; breast milk measured during lactation. In addition, 973 children had information on erythrocyte fatty acid composition and blood pressure at age 12 years. Children who received human milk with an n-3 long-chain polyunsaturated fatty acids content above the median (ie, 0.51 weight percentage) had a 4.79-mm Hg lower systolic (95% CI, -7.64 to -1.94) and a 2.47-mm Hg lower diastolic (95% CI, -4.45 to -0.49) blood pressure at age 12 years than never-breastfed children. N-3 long-chain polyunsaturated fatty acids levels in human milk below the median value and current n-3 long-chain polyunsaturated fatty acid status were not associated with blood pressure at age 12 years. Thus, a relatively high content of n-3 long-chain polyunsaturated fatty acids in human milk is associated with a lower blood pressure in children at age 12 years, a finding not explained by current n-3 long-chain polyunsaturated fatty acids status. (Hypertension. 2012; 60: 1055-1060.). Online Data Supplement

• 出版日期2012-10