Drug Delivery with a Calixpyrrole-trans-Pt(II) Complex

作者：Cafeo Grazia; Carbotti Grazia; Cuzzola Angela; Fabbi Marina; Ferrini Silvano; Kohnke Franz H^*; Papanikolaou Georgia; Plutino Maria Rosaria; Rosano Camillo; White Andrew J P

来源：Journal of the American Chemical Society, 2013, 135(7): 2544-2551.

DOI：10.1021/ja307791j

A meso-p-nitroaniline-calix[4]pyrrole derivative trans-coordinated to a Pt(II) center was synthesized and its structure solved by X-ray analysis. Adenosine monophosphate (AMP) was used as a model compound to evaluate the potential for the assisted delivery of the metal to the DNA nucleobases via the phosphate anion-binding properties of the calix[4]pyrrole unit. An NMR investigation of the kinetics of AMP complexation in the absence of an H-bonding competing solvent (dry CD3CN) was consistent with this hypothesis, but we could not detect the interaction of the calix[4]pyrrole with phosphate in the presence of water. However, in vitro tests of the new trans-calixpyrrole- Pt(II) complex on different cancer cell lines indicate a cytotoxic activity that is unquestionably derived from the coexistence of both the trans-Pt(II) fragment and the calix[4]pyrrole unit.

• 出版日期2013-2-20