Association of the myeloperoxidase polymorphism with the risk of gastric cancer

作者：Hsu, Ping I; Jwo, Jyh Jen; Yang, Chia Lin; Hsu, Ping Ning; Yang, Hsiao Bai; Lai, Kwok Hung; Chen, I Shu; Chuah, Seng Kee; Wu, Deng Chyang; Chen, Angela^*

来源：Anticancer Research, 2008, 28(2B): 1317-1323.

• gastric cancer
• myeloperoxidose
• polymorphism
• Helicobacter pylori
• neutrophil
• gastritis

Background: The myeloperoxidase in neutrophils manufactures many bactericidal oxidants. The aim of this study was to clarify the relations between the myeloperoxidase polymorphism and gastric cancer development. Patients and Methods: In a case control study of 157 consecutive gastric cancer patients and 192 controls, the myeloperoxidase -463G -> A polymorphism was genotyped. Additionally, gastric mucosal changes were examined according to the updated Sydney System. Results: The carriage of myeloperoxidase allele A, male gender, advanced age, high intake of salty food and Helicobacter pylori infection independently increased the risk of gastric cancer [95% confidence interval (CI): 1.5-5.0, 1.7-6.5, 2.6-8.61 1.1-2.6 and 1.2-3.8, respectively]. H. pylori-infected individuals who were carriers of myeloperoxidase allele A had increased risks of both intestinal and diffuse types of gastric cancer with odds ratios of 7.9 (95% CI 2.6-23.5) and 8.6 (95% CI 2.0-36.7), respectively. In the H. pylori-infected individuals, allele A carriers displayed higher scores of bacterial density (p=0.02) and neutrophil infiltration (p=0.05) in the antrum and higher scores of neutrophil infiltration (p=0.02) and gland atrophy (p=0.03) in the corpus than did non-carriers. Conclusion: This study verifies the association of myeloperoxidase -463G -> A polymorphism with gastric cancer. The mechanisms underlying this genetic polymorphism in developing gastric cancer merit further investigations.

• 出版日期2008-4
• 单位长春大学; 中山大学