A mild and facile method for one pot synthesis of 2,5-di-substituted 1,3,4-oxadiazoles at room temperature

作者：Rostamizadeh Shahnaz^*; Ghamkhar Somaye

来源：Chinese Chemical Letters, 2008, 19(6): 639-642.

DOI：10.1016/j.cclet.2008.03.027

• 1,3,4-Oxadiazole
• Acid hydrazide
• Acyl halide
• Phosphorus pentoxide

2,5-Di-substituted 1,3,4-oxadiazoles 3a-n have been synthesized as a one pot procedure from the reaction of acid hydrazide 1, acyl halides 2 and phosphorus pentoxide in acetonitrile at room temperature. High yield, short reaction time (10-15 min), mild condition, and easy work-up are advantages of this methodology.

• 出版日期2008-6