Development and Validation of an Universal Interface for Compound-Specific Stable Isotope Analysis of Chlorine (Cl-37/Cl-35) by GC-High-Temperature Conversion (HTC)-MS/IRMS

作者：Renpenning Julian; Hitzfeld Kristina L; Gilevska Tetyana; Nijenhuis Ivonne; Gehre Matthias^*; Richnow Hans Hermann

来源：Analytical Chemistry, 2015, 87(5): 2832-2839.

DOI：10.1021/ac504232u

A universal application of compound-specific isotope analysis of chlorine was thus far limited by the availability of suitable analysis techniques. In this study, gas chromatography in combination with a high-temperature conversion interface (GC-HTC), converting organic chlorine in the presence of H-2 to gaseous HCl, was coupled to a dual-detection system, combining an ion trap mass spectrometer (MS) and isotope-ratio mass spectrometer (IRMS). The combination of the MS/IRMS detection enabled a detailed characterization, optimization, and online monitoring of the high-temperature conversion process via ion trap MS as well as a simultaneous chlorine isotope analysis by the IRMS. Using GC-HTC-MS/IRMS, chlorine isotope analysis at optimized conversion conditions resulted in very accurate isotope values (delta Cl-37(SMOC)) for measured reference material with known isotope composition, including chlorinated ethylene, chloromethane, hexachlorocyclohexane, and trichloroacetic acids methyl ester. Respective detection limits were determined to be <15 nmol Cl on column with achieved precision of <0.3 parts per thousand.

• 出版日期2015-3-3