An outbreak of dengue virus serotype 1 infection in Cixi, Ningbo, People's Republic of China, 2004, associated with a traveler from Thailand and high density of Aedes albopictus

作者：Xu Guozhang; Dong Hongjun; Shi Nanfeng; Liu Shuian; Zhou Aiming; Cheng Zhihua; Chen Guohua; Liu Jianyi; Fang Ting; Zhang Hongwei; Gu Chunying; Tan Xiaojie; Ye Jianjie; Xie Shuyun; Cao Guangwen^*

来源：The American Journal of Tropical Medicine and Hygiene, 2007, 76(6): 1182-1188.

DOI：10.4269/ajtmh.2007.76.1182

Autochthonous dengue infections have not been reported in Ningbo, People's Republic of China since 1,929. In August-October 2004, an outbreak of dengue fever was confirmed in Xiaolin, Cixi, Ningbo. Of 83 cases reported, 68 were laboratory confirmed. Fifty-three percent (34 of 64) of the cases had IgM antibodies to dengue virus. Dengue virus serotype-1 was isolated from two cases. The outbreak was linked to a traveler who returned from Thailand. Phylogenetic analysis showed that the Ningbo isolate was closely associated to strains from Thailand. Prevalence of dengue-specific IgG in asymptomatic residents was significantly higher in the epidemic-stricken area than in a control area. High density of Aedes albopictus, which resulted from waterlogging caused by Typhoon Rananim and lifestyle of local residents, was responsible for rapid spread of the virus. Eradication of mosquito infestation might interrupt transmission. This outbreak underscores the importance of maintaining surveillance and control of potential vectors for the control of emerging infectious diseases.

• 出版日期2007-6
• 单位中国人民解放军第二军医大学; 浙江省疾病预防控制中心