Hemolysis of the Artificial Red Blood Cell by Microencapsulation of Hemoglobin

作者：Kim Min Ho; Kang Hyung Sub; Kim Jin Shang; Baek Byeong Kirl; Hong Chul Un; Kim Seong Jong; Shin Hyung Shik; Kim Gi Beum^*

来源：Tissue Engineering and Regenerative Medicine, 2010, 7(2): 178-183.

• artificial red blood cell
• microencapsulation
• hemolysis
• hemoglobin
• bovine blood

The purpose of this study was to reduce the hemolysis of artificial red blood cells by extracting phospolipids from egg yolk through microencapsulation to evaluate the oxygen transfer rate of artificial red blood cells in an intravascular artificial lung device. In this study, hemosome was produced to encapsulate hemoglobin which extracted the red blood cell of bovine blood with phospolipids reduced egg yolk. The solution blended blood with hemosome at the rate of 4 to 1 and normal blood measured the oxygen transfer rate. The hemolysis of the microencapsulated artificial red blood cell measured less than the normal red blood cell through absorptivity. Due to the phospolipids enclosing the red blood cell to protect it, the produced hemosome operated at a higher oxygen transfer rate by reducing the demolition of hemoglobin. Consequently, hemolysis was observed to advance through micoencapsulation.

• 出版日期2010-6