Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis

作者：Izumi Hideki; Hirabayashi Kenichi^*; Nakamura Naoya; Nakagohri Toshio

来源：Surgery Today, 2015, 45(4): 487-494.

DOI：10.1007/s00595-015-1126-2

• Pancreatic adenocarcinoma
• Nectins
• E-cadherin
• Cell adhesion molecules
• Prognosis

Nectins are cell adhesion molecules that regulate the formation of adherens junctions and are linked with E-cadherin-based cell-cell adherens junctions. In pancreatic cancer, the expression of E-cadherin and nectins is considered to be related to metastasis, invasion and prognosis.
We evaluated the distribution of cells that were positive for nectin subtypes and E-cadherin using immunohistochemistry in specimens of human pancreatic adenocarcinoma, and correlated these results with the clinicopathological features and patient outcomes.
The immunohistochemical distribution of nectin-1 and E-cadherin showed a good correlation (r = 0.523, p < 0.01). Tumors over 4 cm in diameter had more intense staining for nectin-4 than smaller tumors (p = 0.035). Nectin-2 expression correlated with a poorer histological grade (p = 0.04). The cases that showed diffuse nectin-3 expression had a better prognosis than those with negative expression (p = 0.018).
Our results showed that the expression of nectin-3 in pancreatic cancer can be a prognostic factor.

• 出版日期2015-4