Antihypertensive therapy increases natural immunity response in hypertensive patients

作者：Fonseca Henrique Andrade R; Fonseca Francisco A; Lins Livia C; Monteiro Andrea M; Bianco Henrique T; Brandao Sergio A; Povoa Rui M; Juliano Luiz; Figueiredo Neto Antonio M; Boschcov Paulo; Gidlund Magnus; Izar Maria C^*

来源：Life Sciences, 2015, 143: 124-130.

DOI：10.1016/j.lfs.2015.10.030

• Autoantibodies
• Natural immunity
• Blood pressure
• Hypertension
• Anti-hypertensive therapy

Aims: The aim of this work was to evaluate the effects of treatment of hypertension on the autoantibodies to apolipoprotein B-derived peptides (anti-ApoB-D peptide Abs) response, inflammation markers and vascular function.
Main methods: Eighty-eight patients with hypertension (stage 1 or 2) were recruited and advised to receive perindopril (4 mg), hydrochlorothiazide (25 mg), or indapamide (1.5 mg) for 12 weeks in a blinded fashion. Office and 24-h ambulatory blood pressure monitoring (24 h ABPM), flow-mediated dilatation (FMD), nitrate-induced dilatation (NID), titers of IgG and IgM anti-ApoB-D peptide Abs, hsCRP, and interleukins (IL-8 and IL-10) were evaluated at baseline and 12 weeks after therapies.
Key findings: All treatments reduced office BP, and improved FMD (P < 0.05 vs. baseline). The NID was improved only in the perindopril arm (P< 0.05 vs. baseline). The 24 h-ABPM was reduced with perindopril and hydrochlorothiazide therapies (P < 0.05 vs. baseline), but not with indapamide, and this effect was followed by increase in titers of IgM Anti-ApoB-D peptide Abs (P <0.05 vs. baseline), without modifications in titers IgG Anti-ApoB-D peptide Abs and interleulcins. Multivariable regression analysis has shown that change in the titers of IgM anti-ApoB-D peptide was associated with the changes in FMD (13 0347; P< 0.05).
Significance: These findings shed light to a possible modulator effect of the antihypertensive therapy on the natural immunity responses and vascular function.

• 出版日期2015-12-15