Aberrant expression profiles of isoproterenol-induced endoplasmic reticulum stress response genes in mouse myocardium

作者：Chen, Lin; Zhang, Weiguang; He, Juan; Dong, Qin; Li, Fenglan; Li, Hui^*

来源：Journal of Biochemical and Molecular Toxicology, 2011, 25(6): 382-385.

DOI：10.1002/jbt.20405

• Isoproterenol
• Endoplasmic Reticulum Stress
• Microarray
• Mouse

In this study, we identified the aberrant expression profiles of isoproterenol- (ISO; synthetic catecholamine)induced endoplasmic reticulum (ER) stress response genes in mouse myocardium. Mouse models of acute catecholamine cardiotoxicity were induced by ISO for 6, 12, and 24 h. We performed whole genome oligo microarrays of damaged mouse cardiac tissues, and we found 26 ER stress-related genes whose expression changed significantly for at least one time point. The functional analysis of those genes indicated that myocardial cells were protected by increasing folding capacity, inhibiting general protein translation, and promoting the degradation of misfolded proteins; however, some of them underwent apoptosis in the early stage of ER stress after ISO induced.

• 出版日期2011-11
• 单位哈尔滨医科大学