A NOVEL P-TYPE ATPASE FROM YEAST INVOLVED IN SODIUM-TRANSPORT

作者：HARO R^*; GARCIADEBLAS B; RODRIGUEZN**ARRO A

来源：FEBS LETTERS, 1991, 291(2): 189-191.

DOI：10.1016/0014-5793(91)81280-L

• SODIUM PUMP
• SODIUM ATPASE
• SODIUM EFFLUX
• LITHIUM EFFLUX
• SACCHAROMYCES-CEREVISIAE

The gene ENA1 was cloned by its ability to complement the Li+ sensitivity of a low Li+-efflux strain. The nucleotide sequence of the cloned DNA fragment showed that there are two almost identical genes in tandem, and predicts that they encode P-ATPases. Disruption of both genes originated a strain defective in Na+ and Li+ effluxes, and sensitive to Na+, to Li+ and to alkaline pH. By transformation with ENA1 the defective effluxes and tolerances were repaired.

• 出版日期1991-10-21