Analytical performance of paper electro-biosensor detection platform for point-of-care diagnosis

作者：Tao, ChangBing; Yen, Ching-Shu; Liu, Jen-Tsai^*; Chen, Ching-Jung^*

来源：Cellulose, 2016, 23(6): 3799-3808.

DOI：10.1007/s10570-016-1046-3

• Cellulose paper
• Electro-biosensor detection platform
• Glucose oxidase (GOx)
• Point-of-care diagnosis

A whole paper electro-biosensor detection platform for detecting glucose is reported. Glucose oxidase was immobilized on paper-based screen-printed carbon electrodes. The developed biosensor has an excellent electrochemical characteristic and high heterogeneous electron transfer rate constant (k(s) = 4.23 x 10(-4)). This new detection platform exhibited good amperometric responses toward glucose, with a wide linear range up to 10 mM with R-2 is 0.9973 and the sensitivity is 2.07 mu A mM(-1). The parallel measurements of glucose by different biosensors had a low relative standard deviation of 4.26 % and demonstrated it had good reproducibility. In the interference studies, there was no significant difference with ascorbic acid or uric acid. For stability, it retained 93.9 % of its initial response after a storage period of 31 days in 4 A degrees C. Besides, the Parkes error grid analysis was indicated that paper-based electrochemical biosensor has a good accuracy on the glucose detection.

• 出版日期2016-12
• 单位中国科学院大学