Hsa-miR-449a genetic variant is associated with risk of gastric cancer in a Chinese population

作者：Shi, Jian; Liu, Yangchen; Liu, Jun; Zhou, Juan^*

来源：International Journal of Clinical and Experimental Pathology, 2015, 8(10): 13387-13392.

• Gastric cancer
• miR-449a
• polymorphism

Gastric cancer (GC) is one of the most common malignancies and one of the major causes of cancerrelated deaths worldwide. In the present study, we investigated the association between miR-449a rs112310158 SNP and GC risk. Our findings revealed that a variant GG genotype increased the risk of occurrence of GC compared to a wild type AA genotype (OR = 2.542, 95% CI: 1.304-4.954, P = 0.005). Specifically, the G allele reduced the risk of occurrence of cervical cancer in women compared to the A allele (OR = 1.279, 95% CI: 1.012-1.617, P = 0.043). In conclusion, our findings suggest that miR-449a rs112310158 is a genetic risk factor for GC.

• 出版日期2015
• 单位南通大学