Macular pigment optical density in wet age-related macular degeneration among Indians

作者：Raman R^*; Biswas S; Vaitheeswaran K; Sharma T

来源：Eye, 2012, 26(8): 1052-1057.

DOI：10.1038/eye.2012.86

• macular pigment
• age-related macular degeneration
• carotenoids
• lutein
• zeaxanthin
• ultraviolet

Purpose To estimate the value of macular pigment optical density (MPOD) in adult south Indian population with wet age-related macular degeneration (AMD).
Methods A total of 33 patients with wet AMD and 29 age-matched controls >50 years of age underwent MPOD measurement with the macular densitometer. The patients were also tested for their dietary intake of carotenoids, smoking history, and lifetime UV exposure.
Results The mean MPOD values in the Indian population with wet AMD was 0.23 (95% CI: 0.18-0.29) vs control was 0.43 (95% CI: 0.37-0.49), P<0.0001, at 0.51 eccentricity. Ex-smokers had a lower MPOD than nonsmokers (0.16 (0.09-0.23) vs 0.28 (0.22-0.34), P = 0.026) and the lowest level of carotenoids intake had 48% lower MPOD than the highest level (0.14 (0.08-0.21) vs 0.33 (0.24-0.43), P = 0.012). There was no significant age-related decline or gender variation in MPOD.
Conclusion This study establishes the MPOD in adult Indian population with wet AMD, with a lack of macular pigment in association with wet AMD. Eye (2012) 26, 1052-1057; doi:10.1038/eye.2012.86; published online 25 May 2012

• 出版日期2012-8