Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice

作者：Dray Cedric; Knauf Claude; Daviaud Daniele; Waget Aurelie; Boucher Jeremie; Buleon Marie; Cani Patrice D; Attane Camille; Guigne Charlotte; Carpene Christian; Burcelin Remy; Castan Laurell Isabelle^*; Valet Philippe

来源：Cell Metabolism, 2008, 8(5): 437-445.

DOI：10.1016/j.cmet.2008.10.003

Adipose tissue (AT) secretes several adipokines that influence insulin sensitivity and potentially link obesity to insulin resistance. Apelin, a peptide present in different tissues, is also secreted by adipocytes. Apelin is upregulated in obese and hyperinsulinemic humans and mice. Although a tight relation exists between the regulation of apelin and insulin, it remains largely unknown whether apelin affects whole-body glucose utilization. Herein, we show that in chowfed mice, acute intravenous injection of apelin has a powerful glucose-lowering effect associated with enhanced glucose utilization in skeletal muscle and AT. Through in vivo and in vitro pharmacological and genetic approaches, we demonstrate the involvement of endothelial NO synthase, AMP-activated protein kinase, and Akt in apelin-stimulated glucose uptake in soleus muscle. Remarkably, in obese and insulin-resistant mice, apelin restored glucose tolerance and increased glucose utilization. Apelin could thus represent a promising target in the management of insulin resistance.

• 出版日期2008-11-5
• 单位河北医科大学