Nickel-catalyzed ortho-halogenation of unactivated (hetero)aryl C-H bonds with lithium halides using a removable auxiliary

作者：Zhan, Bei-Bei; Liu, Yan-Hua; Hu, Fang; Shi, Bing-Feng^*

来源：Chemical communications, 2016, 52(27): 4934-4937.

DOI：10.1039/c6cc00822d

• BIDENTATE-CHELATION ASSISTANCE
• CARBON-HYDROGEN BONDS
• C(SP(3))-H BONDS
• COUPLING REACTIONS
• DIRECTING GROUPS
• KINETIC RESOLUTION
• EFFICIENT ACCESS
• DIRECT ARYLATION
• ACTIVATION
• PALLADIUM

The first example of Ni-catalyzed halogenation of (hetero)aryl C-H bonds with lithium halides (LiX, X = Br, I, Cl) using PIP as a removable directing group is reported. This protocol provides an efficient access to ortho-halogenated (hetero) arenes with operational simplicity, good functional group tolerance, and large-scale synthesis.

• 出版日期2016
• 单位浙江大学