Update on stem cell therapy for cerebral palsy

作者：Carroll James E^*; Mays Robert W

来源：Expert Opinion on Biological Therapy, 2011, 11(4): 463-471.

DOI：10.1517/14712598.2011.557060

• animal models
• cerebral palsy
• embryonic stem cells
• induced pluripotent stem cells
• mesenchymal cells
• multipotent adult progenitor cells
• stem cells
• transplantation

Introduction: Due to the publicity about stem cell transplantation for the treatment of cerebral palsy, many families seek information on treatment, and many travel overseas for cell transplantation. Even so, there is little scientific confirmation of benefit, and therefore existing knowledge in the field must be summarized.
Areas covered: This paper addresses the clinical protocols examining the problem, types of stem cells available for transplant, experimental models used to test the benefit of the cells, possible mechanisms of action, potential complications of cell treatment and what is needed in the field to help accelerate cell-based therapies.
Expert opinion: While stem cells may be beneficial in acute injuries of the CNS the biology of stem cells is not well enough understood in chronic injuries or disorders such as cerebral palsy. More work is required at the basic level of stem cell biology, in the development of animal models, and finally in well-conceived clinical trials.

• 出版日期2011-4