Ambulatory Activity Associations With Cardiovascular and Metabolic Risk Factors in Smokers

作者：Julius Brad R^*; Ward B Ann; Stein James H; McBride Patrick E; Fiore Michael C; Colbert Lisa H

来源：Journal of Physical Activity and Health, 2011, 8(7): 994-1003.

• physical activity
• walking
• smoking
• biomarkers
• body mass index

Background: We examined the association between ambulatory activity and biological markers of health in smokers. Methods: Baseline data from 985 subjects enrolled in a pharmacologic smoking cessation trial were examined. Body size, blood pressure, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), total and small LDL particles, LDL size, high density lipoprotein cholesterol, triglycerides (TG), C-reactive protein (CRP), creatinine, fasting glucose, and hemoglobin A1c were assessed in relation to pedometer-assessed ambulatory activity, as was the odds of metabolic syndrome and CRP > 3 mg/L. Effect modification by gender was examined. Results: Only waist circumference was lower with greater steps/day in the men and women combined (P(trend) < 0.001). No other significant relationships were noted in men, while women with >= 7500 steps/day had lower weight, BMI, CRP, TG, total, and small LDL particles compared with those with < 7500 steps/day. These women also had 62% and 43% lower odds of metabolic syndrome and elevated CRP, respectively, compared with the less active women. Adjustment for BMI attenuated all the associations seen in women. Conclusions: Greater ambulatory activity is associated with lower levels of metabolic and cardiovascular risk factors in female smokers which may, in part, be mediated by a reduction in BMI.

• 出版日期2011-9