Associations among q-space MRI, diffusion-weighted MRI and histopathological parameters in meningiomas

作者：Fatima Zareen; Motosugi Utaroh; Waqar Ahmed Bilal; Hori Masaaki; Ishigame Keiichi^*; Oishi Naoki; Onodera Toshiyuki; Yagi Kazuo; Katoh Ryohei; Araki Tsutomu

来源：European Radiology, 2013, 23(8): 2258-2263.

DOI：10.1007/s00330-013-2823-0

• q-Space imaging (QSI)
• Mean displacement (MDP)
• Meningiomas
• Diffusion-weighted imaging (DWI)
• MIB-1 labelling index

The purposes of this MR-based study were to calculate q-space imaging (QSI)-derived mean displacement (MDP) in meningiomas, to evaluate the correlation of MDP values with apparent diffusion coefficient (ADC) and to investigate the relationships among these diffusion parameters, tumour cell count (TCC) and MIB-1 labelling index (LI). %26lt;br%26gt;MRI, including QSI and conventional diffusion-weighted imaging (DWI), was performed in 44 meningioma patients (52 lesions). ADC and MDP maps were acquired from post-processing of the data. Quantitative analyses of these maps were performed by applying regions of interest. Pearson correlation coefficients were calculated for ADC and MDP in all lesions and for ADC and TCC, MDP and TCC, ADC and MIB-1 LI, and MDP and MIB-1 LI in 17 patients who underwent subsequent surgery. %26lt;br%26gt;ADC and MDP values were found to have a strong correlation: r = 0.78 (P = %26lt; 0.0001). Both ADC and MDP values had a significant negative association with TCC: r = -0.53 (p = 0.02) and -0.48 (P = 0.04), respectively. MIB-1 LI was not, however, found to have a significant association with these diffusion parameters. %26lt;br%26gt;In meningiomas, both ADC and MDP may be representative of cell density.

• 出版日期2013-8